Dynamic multi-level models of cardiac tissue

Wilson, Craig (2015) Dynamic multi-level models of cardiac tissue. BSc dissertation, University of Portsmouth.

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    Models of electrical wave propagation are an important tool for biomedical scientists to further their understanding of cardiac tissues. Rhythmical mechanical contractions of the heart are generated by electrical waves. When the waves cannot propagate through the heart properly, they alter the heart’s rhythm. This is what is causing conditions like arrhythmias, a common cause of sudden cardiac deaths.
    Many cardiac models exist, but are either too omputationally expensive or lack important cardiac cells characteristics. This project aims to simulate a complex model embedded in a simple one. The complex model is used for the area of interest while the simple one is used for most of the cell elements. This severely decreases the number of calculations required, therefore decreasing the time required for running the simulation. In order to keep the embedded region in the area of interest, three manipulation techniques have been developed. Next, a dynamic approach is taken, where embedded regions are created depending on properties of current wave propagations, followed by a comparison of the methods conducted.

    Item Type: Dissertation
    Departments/Research Groups: Faculty of Technology > School of Computing
    Depositing User: Jane Polwin
    Date Deposited: 03 Dec 2015 14:58
    Last Modified: 03 Dec 2015 14:58
    URI: http://eprints.port.ac.uk/id/eprint/19061

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