What impact does statin therapy have on periodontal health?

Basra, Kiran (2013) What impact does statin therapy have on periodontal health? BSc dissertation, University of Portsmouth.

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    Background: Recent developments in the field of statins and its pleiotropic effects have led to a renewed interest in its potential role in periodontal disease. Inflammatory mechanisms partake in the development of CVD and the evidence suggesting that CVD and periodontal disease share common risk factors are widely recognised. Statins have been successful in the prevention and treatment of CVD and the discovery of the pleiotropic effects have led to further exploration outside of the management of CVD. The suggested anti-inflammatory effects of statins are thought to have a beneficial impact on chronic periodontitis. It is this element which will be explored as to whether the drugs could be considered promising in the future to reduce periodontitis.

    Aim: To determine to what extent statin medication affects the periodontal condition and whether the influence is considered to be positive or negative.

    Methods/Materials: By critical appraisal of literature of six previously conducted studies using Roe’s (1993) model. Articles published in the last ten years were of prime focus.

    Results: Statins play a role which might ameliorate the periodontal condition in terms of reducing inflammation; a significant periodontal parameter.

    Conclusion: Statin medication appears to have a positive effect within the constraints of the studies discussed. Further evidence is acknowledged to understand the precise mode of action of statins in relation to periodontal disease and validate the findings. This will be a critical component in assessing progression of research.

    Item Type: Dissertation
    Departments/Research Groups: Faculty of Science > Portsmouth Dental Academy
    Depositing User: Jane Polwin
    Date Deposited: 22 Oct 2013 16:37
    Last Modified: 28 Jan 2015 12:30
    URI: http://eprints.port.ac.uk/id/eprint/13685

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